Temporal Progression of Drosophila Neural Stem Cells Promoting Neuronal Diversity
| dc.contributor.advisor | Doe, Chris | |
| dc.contributor.author | Dillon, Noah | |
| dc.date.accessioned | 2025-02-24T19:07:08Z | |
| dc.date.available | 2025-02-24T19:07:08Z | |
| dc.date.issued | 2025-02-24 | |
| dc.description.abstract | How are complex nervous systems generated? During development, a small pool of neural stem cells generates a diverse array of cell type diversity that forms a functional brain. Remarkably, this neuronal diversity is generated in a predictable order. In this dissertation, I report my work in understanding how neural stem cells of the developing Drosophila melanogaster, known as neuroblasts, are temporally patterned. My work has established a single-cell RNA sequencing atlas of the early larval stages of neurogenesis that identified key regulators of how neuroblasts progress from a quiescent to a proliferative state. My subsequent studies focused on neuroblast lineages that generate the central brain of the adult. I show that the transcription factor Seven-up is required for switching the production of early to late neuron identities and progressing Type 2 neuroblasts to the end of their lineage (i.e. death). Finally, I show the temporal transcription factor Castor is required for specifying neuron identities born in early larval Type 2 neuroblast lineages. My work shows significant advancements in understanding how the fly brain is generated and provides fruitful future directions to pursue. | en_US |
| dc.identifier.uri | https://hdl.handle.net/1794/30439 | |
| dc.language.iso | en_US | |
| dc.publisher | University of Oregon | |
| dc.rights | All Rights Reserved. | |
| dc.title | Temporal Progression of Drosophila Neural Stem Cells Promoting Neuronal Diversity | |
| dc.type | Electronic Thesis or Dissertation | |
| thesis.degree.discipline | Department of Biology | |
| thesis.degree.grantor | University of Oregon | |
| thesis.degree.level | doctoral | |
| thesis.degree.name | Ph.D. |
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